Colq^tm2Jrs
Targeted Allele Detail

Summary

• Symbol: Colq^tm2Jrs
• Name: collagen like tail subunit of asymmetric acetylcholinesterase; targeted mutation 2, Joshua R Sanes
• MGI ID: MGI:1857734
• Gene: Colq Location: Chr14:31245039-31299820 bp, - strand Genetic Position: Chr14, 19.18 cM, cytoband B
• Alliance: Colq^tm2Jrs page

Synapses in some Colq^tm1Jrs/Colq^tm1Jrs muscle appear immature or fragmented

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:54006
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An in frame lacZ gene and a neomycin resistance cassette replaced 0.6 kb of sequence containing the exon that encodes the proline rich domain. (J:54006)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Colq Mutation: 27 strains or lines available

Notes

The phenotype of homozygous mutant mice is identical to that reported for Colq^tm1Jrs:

References

• Original: J:54006 Feng G, et al., Genetic analysis of collagen Q: roles in acetylcholinesterase and butyrylcholinesterase assembly and in synaptic structure and function. J Cell Biol. 1999 Mar 22;144(6):1349-60
• All: 2 reference(s)