Colq^tm1Jrs
Targeted Allele Detail

Nomenclature

Symbol:	Colq^tm1Jrs
Name:	collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase; targeted mutation 1, Joshua R Sanes
MGI ID:	MGI:1857733
Gene:	Colq  Location: Chr14:31523082-31591343 bp, - strand  Genetic Position: Chr14, 19.18 cM, cytoband B

Synapses in some Colq^tm1Jrs/Colq^tm1Jrs muscle appear immature or fragmented

Show the 2 phenotype image(s) involving this allele.

Mutation origin

Germline Transmission:	Earliest citation of germline transmission: J:54006
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl^+

Mutation description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A neomycin resistance cassette replaced 0.8 kb of sequence containing the exon encoding the proline rich domain. (J:54006)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Colq Mutation:	2 strains or lines available

References

Original:	J:54006 Feng G, et al., Genetic analysis of collagen Q: roles in acetylcholinesterase and butyrylcholinesterase assembly and in synaptic structure and function. J Cell Biol. 1999 Mar 22;144(6):1349-60
All:	4 reference(s)