Colq^tm1Jrs
Targeted Allele Detail

Nomenclature

• Symbol: Colq^tm1Jrs
• Name: collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase; targeted mutation 1, Joshua R Sanes
• MGI ID: MGI:1857733
• Gene: Colq Location: Chr14:31523082-31591343 bp, - strand Genetic Position: Chr14, 19.18 cM, cytoband B

Synapses in some Colq^tm1Jrs/Colq^tm1Jrs muscle appear immature or fragmented

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:54006
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced 0.8 kb of sequence containing the exon encoding the proline rich domain. (J:54006)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structures

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Colq Mutation: 16 strains or lines available

References

• Original: J:54006 Feng G, et al., Genetic analysis of collagen Q: roles in acetylcholinesterase and butyrylcholinesterase assembly and in synaptic structure and function. J Cell Biol. 1999 Mar 22;144(6):1349-60
• All: 5 reference(s)