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Colqtm1Jrs
Targeted Allele Detail
Summary
Symbol: Colqtm1Jrs
Name: collagen like tail subunit of asymmetric acetylcholinesterase; targeted mutation 1, Joshua R Sanes
MGI ID: MGI:1857733
Gene: Colq  Location: Chr14:31245039-31299820 bp, - strand  Genetic Position: Chr14, 19.18 cM, cytoband B
Alliance: Colqtm1Jrs page
Synapses in some Colqtm1Jrs/Colqtm1Jrs muscle appear immature or fragmented

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:54006
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced 0.8 kb of sequence containing the exon encoding the proline rich domain. (J:54006)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Colq Mutation:  27 strains or lines available
References
Original:  J:54006 Feng G, et al., Genetic analysis of collagen Q: roles in acetylcholinesterase and butyrylcholinesterase assembly and in synaptic structure and function. J Cell Biol. 1999 Mar 22;144(6):1349-60
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory