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Blmtm1Ches
Targeted Allele Detail
Nomenclature
Symbol: Blmtm1Ches
Name: Bloom syndrome, RecQ helicase-like; targeted mutation 1, Nicholas Chester
MGI ID: MGI:1857708
Synonyms: Blm-, Blmneo
Gene: Blm  Location: Chr7:80454993-80535119 bp, - strand  Genetic Position: Chr7, 45.65 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:50843
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced 180 bp of exon 8. Faint transcripts of altered mobility were detected in Northern blot analysis on RNA derived from embryonic fibroblasts of homozygous mice. (J:50843, J:112115)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 2 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Blm Mutation:  30 strains or lines available
References
Original:  J:50843 Chester N, et al., Stage-specific apoptosis, developmental delay, and embryonic lethality in mice homozygous for a targeted disruption in the murine Bloom's syndrome gene. Genes Dev. 1998 Nov 1;12(21):3382-93
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/13/2015
MGI 5.21
The Jackson Laboratory