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Rac2tm1Mddw
Targeted Allele Detail
Nomenclature
Symbol: Rac2tm1Mddw
Name: Rac family small GTPase 2; targeted mutation 1, Mary C Dinauer and David A Williams
MGI ID: MGI:1857701
Synonyms: rac2-, Rac2tm1Daw
Gene: Rac2  Location: Chr15:78559169-78572783 bp, - strand  Genetic Position: Chr15, 37.57 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:53362
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced a genomic fragment containing exon 1, which encodes the translational initiation site and part of the GTP-binding domain. Northern blot and RT-PCR analysis demonstrated that no transcripts were detectable in total RNA derived from neutrophils or lymphocytes in homozygous mice. Western blot analysis confirmed an absence of protein produced from this allele in peritoneal exudate cells from homozygous mice. (J:53362)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rac2 Mutation:  1 strain or line available
References
Original:  J:53362 Roberts AW, et al., Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense. Immunity. 1999 Feb;10(2):183-96
All:  71 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory