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Smad4tm1Mmt
Targeted Allele Detail
Nomenclature
Symbol: Smad4tm1Mmt
Name: SMAD family member 4; targeted mutation 1, Makoto M Taketo
MGI ID: MGI:1857697
Synonyms: Dpc4(-)
Gene: Smad4  Location: Chr18:73639009-73703780 bp, - strand  Genetic Position: Chr18, 49.51 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:46242
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation details
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Smad4 Mutation:  12 strains or lines available
Notes
Phenotypic Similarity to Human Syndrome: colorectal adenocarcinomas (Apctm1Mmt Smad4tm1Mmt heterozygotes J:46242)

References
Original:  J:46242 Takaku K, et al., Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes. Cell. 1998 Mar 6;92(5):645-56
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory