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Targeted Allele Detail
Symbol: Smad3tm1Xfw
Name: SMAD family member 3; targeted mutation 1, Xiao Fan Wang
MGI ID: MGI:1857696
Synonyms: Smad3-, Smad3null
Gene: Smad3  Location: Chr9:63646767-63757994 bp, - strand  Genetic Position: Chr9, 34.22 cM, cytoband D
Germline Transmission:  Earliest citation of germline transmission: J:53948
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced the first exon and part of the first intron, including the initiating ATG codon. (J:53948)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Smad3 Mutation:  3 strains or lines available
Phenotypic Similarity to Human Syndrome: Holoprosencephaly in mice homozygous for Nogtm1Amc and heterozygous for Smad3tm1Xfw in J:161524

Original:  J:53948 Datto MB, et al., Targeted disruption of Smad3 reveals an essential role in transforming growth factor beta-mediated signal transduction. Mol Cell Biol. 1999 Apr;19(4):2495-504
All:  23 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory