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Targeted Allele Detail
Symbol: Smad3tm1Cxd
Name: SMAD family member 3; targeted mutation 1, Chu-Xia Deng
MGI ID: MGI:1857695
Synonyms: Smad3-, Smad3delEx8, Smad3ex8
Gene: Smad3  Location: Chr9:63646767-63757994 bp, - strand  Genetic Position: Chr9, 34.22 cM, cytoband D
Skeletal defects in 7 month old Smad3tm1Cxd/Smad3tm1Cxd mice

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:53510
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced exon 8 of the gene, which truncated the protein 89 amino acids from the C-terminal end. (J:53510)
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Smad3 Mutation:  3 strains or lines available
Original:  J:53510 Yang X, et al., Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta. EMBO J. 1999 Mar 1;18(5):1280-91
All:  105 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.21
The Jackson Laboratory