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VcanTg(Hoxa1)1Chm
Transgenic Allele Detail
Nomenclature
Symbol: VcanTg(Hoxa1)1Chm
Name: versican; transgene insertion 1, Corey H Mjaatvedt
MGI ID: MGI:1857689
Synonyms: Cspg2hdf, hdf, hdf, heart defect, Vcanhdf
Gene: Vcan  Location: Chr13:89655312-89742509 bp, - strand  Genetic Position: Chr13, 45.5 cM
Transgene
origin
Strain of Origin:  C57BL/6J or CBA
Transgene
description
Transgene Type:    Transgenic (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsThe transgene consisted of 3.5kb of the Hoxa1 regulatory region gene with a lacZ reporter sequence. The transgene inserted into intron 7 and separates exons 7 and 8, which code for the two chondroitin sulfate binding domains. RT-PCR analysis detected truncated mRNA transcripts in homozygous embryos. None of the alternative splice forms of the gene are detected in hearts from homozygous mice. (J:50233)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Vcan Mutation:  9 strains or lines available
References
Original:  J:41016 Yamamura H, et al., A heart segmental defect in the anterior-posterior axis of a transgenic mutant mouse. Dev Biol. 1997 Jun 1;186(1):58-72
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory