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Targeted Allele Detail
Symbol: Tgfb1tm1N
Name: transforming growth factor, beta 1; targeted mutation 1, National Institutes of Health
MGI ID: MGI:1857671
Synonyms: Tgfb1-, TGF-beta1-
Gene: Tgfb1  Location: Chr7:25687002-25705077 bp, + strand  Genetic Position: Chr7, 13.98 cM
Histopathological analysis on lung and heart tissues of Tgfb1tm1N/Tgfb1tm1N mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:50848
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsPart of the first exon and intron was replaced by a phosphoglycerate kinase-neomycin resistance gene. (J:18881, J:50848)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 5 assay results
In Structures Affected by this Mutation: 15 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tgfb1 Mutation:  22 strains or lines available
Original:  J:50848 Kulkarni AB, et al., Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death. Proc Natl Acad Sci U S A. 1993 Jan 15;90(2):770-4
All:  69 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory