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Cdh5tm1Hub
Targeted Allele Detail
Nomenclature
Symbol: Cdh5tm1Hub
Name: cadherin 5; targeted mutation 1, Philippe Huber
MGI ID: MGI:1857669
Synonyms: VE-cadherin-
Gene: Cdh5  Location: Chr8:104101625-104144511 bp, + strand  Genetic Position: Chr8, 53.04 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:54177
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced part of exon 2, including sequences encoding the initiation codon, the signal peptide, the propeptide and the first 9 amino acids of the mature protein. (J:40971)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 67 assay results
In Structures Affected by this Mutation: 10 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cdh5 Mutation:  5 strains or lines available
References
Original:  J:54177 Gory-Faure S, et al., Role of vascular endothelial-cadherin in vascular morphogenesis. Development. 1999 May;126(10):2093-102
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/23/2020
MGI 6.15
The Jackson Laboratory