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Targeted Allele Detail
Symbol: Prrx1tm1Tex
Name: paired related homeobox 1; targeted mutation 1, University of Texas
MGI ID: MGI:1857640
Synonyms: Prx1-, Prx1LacZ, Prx-1neo
Gene: Prrx1  Location: Chr1:163245119-163313710 bp, - strand  Genetic Position: Chr1, 70.53 cM
Germline Transmission:  Earliest citation of germline transmission: J:25649
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA PGK-neomycin cassette was inserted into the 5' region of the homeobox domain. RT-PCR analysis failed to detect gene specific transcript in homozygous mutant animals. (J:25649)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 61 assay results
In Structures Affected by this Mutation: 40 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Prrx1 Mutation:  5 strains or lines available
Original:  J:25649 Martin JF, et al., The paired-like homeo box gene MHox is required for early events of skeletogenesis in multiple lineages. Genes Dev. 1995 May 15;9(10):1237-49
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory