Edn1tm1Utj
Targeted Allele Detail
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Symbol: |
Edn1tm1Utj |
Name: |
endothelin 1; targeted mutation 1, University of Tokyo |
MGI ID: |
MGI:1857637 |
Synonyms: |
EdnRA-, ET-1- |
Gene: |
Edn1 Location: Chr13:42454952-42461466 bp, + strand Genetic Position: Chr13, 20.82 cM
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Alliance: |
Edn1tm1Utj page
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Cardiovascular abnormalities in Edn1tm1Utj/Edn1tm1Utj mice at 18.5 dpc
Show the 3 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:17694
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Parent Cell Line: |
A3-1 (ES Cell)
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Strain of Origin: |
129X1/SvJ
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Allele Type: |
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Targeted (Null/knockout) |
Mutation: |
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Insertion
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Mutation details: A neomycin resistance gene was inserted into exon 2, which encodes the mature peptide. RT-PCR analysis on RNA derived from homozygous embryos demonstrated that no detectable transcript was produced from this allele. Enzyme immunoassay tests confirmed that no active peptide was present in lung extracts of homozygous mice.
(J:17694)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Edn1 Mutation: |
25 strains or lines available
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Original: |
J:17694 Kurihara Y, et al., Elevated blood pressure and craniofacial abnormalities in mice deficient in endothelin-1 [see comments]. Nature. 1994 Apr 21;368(6473):703-10 |
All: |
31 reference(s) |
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