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Targeted Allele Detail
Symbol: Phc1tm1Os
Name: polyhomeotic 1; targeted mutation 1, Osaka University Medical School
MGI ID: MGI:1857629
Synonyms: rae28 -
Gene: Phc1  Location: Chr6:122317731-122340227 bp, - strand  Genetic Position: Chr6, 57.52 cM, cytoband F3
Phc1tm1Os/Phc1tm1Os hearts show abnormal cardiac looping at E9.5

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:43764
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA promoterless neomycin resistance gene was inserted in-frame into exon 4, and a fragement containing exons 5 and 6 was deleted. Western blot analysis on whole E13.5 embryo lysates confirmed that no detectable encoded protein was made in homozygous mice. (J:43764)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 71 assay results
In Structures Affected by this Mutation: 27 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Phc1 Mutation:  34 strains or lines available
Original:  J:43764 Takihara Y, et al., Targeted disruption of the mouse homologue of the Drosophila polyhomeotic gene leads to altered anteroposterior patterning and neural crest defects. Development. 1997 Oct;124(19):3673-82
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory