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Targeted Allele Detail
Symbol: Raratm1Ipc
Name: retinoic acid receptor, alpha; targeted mutation 1, Pierre Chambon
MGI ID: MGI:1857622
Synonyms: Aalpha, Rara-, RARalpha-
Gene: Rara  Location: Chr11:98927818-98974942 bp, + strand  Genetic Position: Chr11, 62.76 cM, cytoband D-E1
Degenerative lesions in testes of 4 to 5 month old Raratm1Ipc/Raratm1Ipc mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:13574
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin cassette was inserted into exon 8, which encodes the common receptor region B. This disruption is predicted to prevent the synthesis of all Rara isoforms. RNAase protection analysis of homozygous E13.5 embryos failed to detect wild type RNA transcripts and immunoblot analysis failed to detect protein in in extracts from homozygous E13.5 embryos. (J:13574)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 116 assay results
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rara Mutation:  73 strains or lines available
Original:  J:13574 Lufkin T, et al., High postnatal lethality and testis degeneration in retinoic acid receptor alpha mutant mice. Proc Natl Acad Sci U S A. 1993 Aug 1;90(15):7225-9
All:  31 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory