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Radiation induced Allele Detail
Symbol: Cryget
Name: crystallin, gamma E; total opacity and microphthalmia
MGI ID: MGI:1857598
Synonyms: Cat-2t, Cat2t, CrygeCat2-t, R-324
Gene: Cryge  Location: Chr1:65048554-65051149 bp, - strand  Genetic Position: Chr1, 32.8 cM
Strain of Origin:  (102/El x C3H/El)F1
Allele Type:    Radiation induced
Mutation:    Single point mutation
Mutation detailsA C to G transversion at nucleotide position 432 in exon 3 of Cryge that creates a premature termination signal and results in a truncated protein after amino acid 143. (J:50319)
Inheritance:    Dominant
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cryge Mutation:  9 strains or lines available

With the discovery that the mutation is a nucleotide substitution, it has been suggested that CrygeCat2-t may have possibly been spontaneous instead of X-ray induced J:50319.

Phenotypic Similarity to Human Syndrome: Dominant Cataracts in heterozygous and homozygous mice mice (J:9528)

Original:  J:52633 Graw J, et al., Dominant cataract and recessive specific locus mutations in offspring of X-irradiated male mice. Mutat Res. 1986 Jan-Feb;159(1-2):47-54
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.04
The Jackson Laboratory