About   Help   FAQ
Cryget
Radiation induced Allele Detail
Nomenclature
Symbol: Cryget
Name: crystallin, gamma E; total opacity and microphthalmia
MGI ID: MGI:1857598
Synonyms: Cat-2t, Cat2t, CrygeCat2-t, R-324
Gene: Cryge  Location: Chr1:65048554-65051149 bp, - strand  Genetic Position: Chr1, 32.8 cM
Mutation
origin
Strain of Origin:  (102/El x C3H/El)F1
Mutation
description
Allele Type:    Radiation induced
Mutation:    Single point mutation
 
Mutation details
Inheritance:    Dominant
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cryge Mutation:  7 strains or lines available
Notes
Arose in descendants of X-irradiated (102/El X C3H/El)F1 mice and originally called R-324 (J:23991, J:52633). Homozygotes and heterozygotes have total lens opacity and dysplasia, iris dysplasia with small pupils, and microphthalmia (J:9528). The epithelial and fiber cells swell and the lens capsule ruptures (J:23991). There is complete destruction of lens cellular organization. The biochemistry of the cataractous lenses is also affected in the osmotic, energy, and redox states, probably as a secondary effect. Changes in vimentin and transglutamase, however, may be more directly connected with developmental changes (J:23991).

With the discovery that the mutation is a nucleotide substitution, it has been suggested that CrygeCat2-t may have possibly been spontaneous instead of X-ray induced J:50319.

Phenotypic Similarity to Human Syndrome: Dominant Cataracts in heterozygous and homozygous mice mice (J:9528)

References
Original:  J:52633 Graw J, et al., Dominant cataract and recessive specific locus mutations in offspring of X-irradiated male mice. Mutat Res. 1986 Jan-Feb;159(1-2):47-54
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/08/2014
MGI 5.17
The Jackson Laboratory