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Targeted Allele Detail
Symbol: Braftm1Zim
Name: Braf transforming gene; targeted mutation 1, Andreas Zimmer
MGI ID: MGI:1857579
Synonyms: B-raf-, Braf-, Braftm1Pig
Gene: Braf  Location: Chr6:39603237-39725463 bp, - strand  Genetic Position: Chr6, 18.43 cM
Germline Transmission:  Earliest citation of germline transmission: J:41257
Parent Cell Line:  MPI-II (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin selection cassette was inserted into exon 3, which encodes the N-terminal portion of the Ras-binding domain. Northern blot analysis on RNA derived from E10.5 embryos demonstrated that no detectable transcript is produced from this allele. (J:41257)
Inheritance:    Recessive
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 12 assay results
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Braf Mutation:  13 strains or lines available
Original:  J:41257 Wojnowski L, et al., Endothelial apoptosis in Braf-deficient mice [see comments]. Nat Genet. 1997 Jul;16(3):293-7
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.15
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