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Hmx3tm1Tlu
Targeted Allele Detail
Nomenclature
Symbol: Hmx3tm1Tlu
Name: H6 homeobox 3; targeted mutation 1, Tom Lufkin
MGI ID: MGI:1857577
Synonyms: Hmx3neo
Gene: Hmx3  Location: Chr7:131542867-131544925 bp, + strand  Genetic Position: Chr7, 74.32 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:46379
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Disruption caused by insertion of vector
 
Mutation detailsA neomycin resistance cassette was inserted into the homeobox sequence of the gene, resulting in the truncation of the protein in the N-terminal portion of the homeodomain. (J:46379)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hmx3 Mutation:  7 strains or lines available
Notes
ES cell line = R1 ((129X1/SvJ x 129S1/Sv)F1-Kitl+) or D3 (129S2/SvPas).
References
Original:  J:46379 Wang W, et al., Inner ear and maternal reproductive defects in mice lacking the Hmx3 homeobox gene. Development. 1998 Feb;125(4):621-34
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory