Hmx3^tm1Tlu
Targeted Allele Detail

Summary

• Symbol: Hmx3^tm1Tlu
• Name: H6 homeobox 3; targeted mutation 1, Tom Lufkin
• MGI ID: MGI:1857577
• Synonyms: Hmx3^neo
• Gene: Hmx3 Location: Chr7:131144596-131146654 bp, + strand Genetic Position: Chr7, 74.32 cM
• Alliance: Hmx3^tm1Tlu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:46379
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Disruption caused by insertion of vector
• Mutation details: A neomycin resistance cassette was inserted into the homeobox sequence of the gene, resulting in the truncation of the protein in the N-terminal portion of the homeodomain. (J:46379)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hmx3 Mutation: 15 strains or lines available

Notes

ES cell line = R1 ((129X1/SvJ x 129S1/Sv)F1-Kitl⁺) or D3 (129S2/SvPas).

References

• Original: J:46379 Wang W, et al., Inner ear and maternal reproductive defects in mice lacking the Hmx3 homeobox gene. Development. 1998 Feb;125(4):621-34
• All: 1 reference(s)