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Runx1tm1Spe
Targeted Allele Detail
Nomenclature
Symbol: Runx1tm1Spe
Name: runt related transcription factor 1; targeted mutation 1, Nancy A Speck
MGI ID: MGI:1857568
Synonyms: Cbfa2-, Cbfa2rd, Runx1-, Runx1deltaE4, Runx1rd
Gene: Runx1  Location: Chr16:92601466-92826149 bp, - strand  Genetic Position: Chr16, 53.7 cM
Gross and microscopic views of pathologic lesions in Runx1tm1Spe/Runx1tm1Spe mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:35115
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 4, which encodes a portion of the DNA-binding domain, was replaced with a PGK-neo cassette. RT-PCR analysis showed a lack of normal transcript in homozygous mutant mice. (J:35115)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 8 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Runx1 Mutation:  18 strains or lines available
References
Original:  J:35115 Wang Q, et al., Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis. Proc Natl Acad Sci U S A. 1996 Apr 16;93(8):3444-9
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory