Mgat1^tm1Pst
Targeted Allele Detail

Summary

• Symbol: Mgat1^tm1Pst
• Name: mannoside acetylglucosaminyltransferase 1; targeted mutation 1, Pamela Stanley
• MGI ID: MGI:1857564
• Synonyms: Mgat1^-
• Gene: Mgat1 Location: Chr11:49135018-49153854 bp, + strand Genetic Position: Chr11, 29.27 cM
• Alliance: Mgat1^tm1Pst page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:16489
• Parent Cell Line: WW6 (ES Cell)
• Strain of Origin: STOCK 129/Sv and C57BL/6J and SJL

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Insertion of a neomycin cassette into the coding exon. Protein activity was not detected in homozyogous mutant embryos. (J:16489)

Expression

In Mice Carrying this Mutation:	14 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mgat1 Mutation: 18 strains or lines available

References

• Original: J:16489 Ioffe E, et al., Mice lacking N-acetylglucosaminyltransferase I activity die at mid-gestation, revealing an essential role for complex or hybrid N-linked carbohydrates. Proc Natl Acad Sci U S A. 1994 Jan 18;91(2):728-32
• All: 5 reference(s)