Cftr^tm1Hsc
Targeted Allele Detail

Summary

• Symbol: Cftr^tm1Hsc
• Name: cystic fibrosis transmembrane conductance regulator; targeted mutation 1, Hospital for Sick Children
• MGI ID: MGI:1857545
• Synonyms: Cftr^m1HSC
• Gene: Cftr Location: Chr6:18170686-18322767 bp, + strand Genetic Position: Chr6, 8.1 cM, cytoband A3
• Alliance: Cftr^tm1Hsc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:31759
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• A neomycin resistance cassette was inserted into exon 1. (J:31759)

Disease models

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cftr Mutation: 97 strains or lines available

References

• Original: J:31759 Rozmahel R, et al., Modulation of disease severity in cystic fibrosis transmembrane conductance regulator deficient mice by a secondary genetic factor [published erratum appears in Nat Genet 1996 May;13(1):129]. Nat Genet. 1996 Mar;12(3):280-7
• All: 5 reference(s)