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Juptm1Kem
Targeted Allele Detail
Nomenclature
Symbol: Juptm1Kem
Name: junction plakoglobin; targeted mutation 1, Rolf Kemler
MGI ID: MGI:1857539
Synonyms: Pg-, plako-
Gene: Jup  Location: Chr11:100368958-100397763 bp, - strand  Genetic Position: Chr11, 63.47 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:38047
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    A neomycin resistance cassette replaced exons 3 and 4 of the gene. (J:38047)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 32 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Jup Mutation:  129 strains or lines available
References
Original:  J:38047 Bierkamp C, et al., Embryonic heart and skin defects in mice lacking plakoglobin. Dev Biol. 1996 Dec 15;180(2):780-5
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory