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Map2k4tm1Pngr
Targeted Allele Detail
Nomenclature
Symbol: Map2k4tm1Pngr
Name: mitogen-activated protein kinase kinase 4; targeted mutation 1, Josef M Penninger
MGI ID: MGI:1857536
Synonyms: Epha4tm1Oci, Sek1 -
Gene: Map2k4  Location: Chr11:65688243-65788297 bp, - strand  Genetic Position: Chr11, 40.53 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:77942
Parent Cell Line:  E14K (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 2 was disrupted by the insertion of a neomycin selection cassette. Neither transcript nor protein was detected in homozygous mutant ES cells. (J:77942)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 11 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Map2k4 Mutation:  16 strains or lines available
References
Original:  J:77942 Nishina H, et al., Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3. Nature. 1997 Jan 23;385(6614):350-3
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory