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Ngftm1Gne
Targeted Allele Detail
Nomenclature
Symbol: Ngftm1Gne
Name: nerve growth factor; targeted mutation 1, Genentech
MGI ID: MGI:1857535
Synonyms: NGF-, Ngfbtm1
Gene: Ngf  Location: Chr3:102469919-102521013 bp, + strand  Genetic Position: Chr3, 45.25 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:17792
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsReplacement of a 150 bp fragment of the Ngfb gene, including the exon IV splice acceptor site and 130-bp of NGF coding sequence including the translation start site, with a CMV-neomycin cassette. (J:17792)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 18 assay results
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ngf Mutation:  7 strains or lines available
References
Original:  J:17792 Crowley C, et al., Mice lacking nerve growth factor display perinatal loss of sensory and sympathetic neurons yet develop basal forebrain cholinergic neurons. Cell. 1994 Mar 25;76(6):1001-11
All:  33 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory