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Rxratm1Ipc
Targeted Allele Detail
Nomenclature
Symbol: Rxratm1Ipc
Name: retinoid X receptor alpha; targeted mutation 1, Pierre Chambon
MGI ID: MGI:1857511
Synonyms: Rxr alpha AF2I, Rxralphaaf2(l), Rxr alpha AF2O
Gene: Rxra  Location: Chr2:27676440-27762957 bp, + strand  Genetic Position: Chr2, 19.38 cM
Rxratm1Ipc/Rxratm4Ipc Rxrbtm1Mma/Rxrbtm1Pcn Tg(KRT14-cre/ERT2)1Ipc/0 mice develop alopecia but no skin inflammation while Rxratm4Ipc/Rxratm4Ipc Rxrbtm1Pcn/Rxrbtm1Pcn Tg(KRT14-cre/ERT2)1Ipc/0 mice show both hair loss and skin inflammation

Show the 1 image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:50515
Parent Cell Line:  H1 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (knock-out)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation details
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 2 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rxra Mutation:  6 strains or lines available
References
Original:  J:50515 Mascrez B, et al., The RXRalpha ligand-dependent activation function 2 (AF-2) is important for mouse development. Development. 1998 Dec;125(23):4691-707
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory