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Gja8No2
Chemically induced Allele Detail
Summary
Symbol: Gja8No2
Name: gap junction protein, alpha 8; nuclear opacity 2
MGI ID: MGI:1857499
Synonyms: Cx50D47A, ENU-326, No2
Gene: Gja8  Location: Chr3:96820882-96833336 bp, - strand  
Alliance: Gja8No2 page
Mutation
origin
Strain of Origin:  (101 x C3H)F1
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
 
Mutation detailsAn A-to-C transversion in the coding region mutated codon 47. This results in the nonconservative substitution of alanine for aspartic acid in a highly conserved region of the first extracellular loop of the peptide. (J:49492)
Inheritance:    Semidominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Gja8 Mutation:  33 strains or lines available
References
Original:  J:21950 Favor J, A comparison of the dominant cataract and recessive specific-locus mutation rates induced by treatment of male mice with ethylnitrosourea. Mutat Res. 1983 Aug;110(2):367-82
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory