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Wnt3atm1Amc
Targeted Allele Detail
Nomenclature
Symbol: Wnt3atm1Amc
Name: wingless-type MMTV integration site family, member 3A; targeted mutation 1, Andrew P McMahon
MGI ID: MGI:1857489
Synonyms: Wnt-3a-, Wnt3a-, Wnt3aneo
Gene: Wnt3a  Location: Chr11:59138862-59181577 bp, - strand  Genetic Position: Chr11, 37.17 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:16716
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsThe insertion of neomycin selection cassette into exon 3 introduced a stop codon that results in a truncated peptide approximately one-third the normal size. Transcription of the targeted loci was detected in homozygous mutant embryos via in situ hybridization. (J:16716, J:39344)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 135 assay results
In Structures Affected by this Mutation: 18 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Wnt3a Mutation:  23 strains or lines available
References
Original:  J:16716 Takada S, et al., Wnt-3a regulates somite and tailbud formation in the mouse embryo. Genes Dev. 1994 Jan;8(2):174-89
All:  32 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/17/2022
MGI 6.19
The Jackson Laboratory