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Targeted Allele Detail
Symbol: Gcktm1Ts
Name: glucokinase; targeted mutation 1, Timothy Stewart
MGI ID: MGI:1857469
Synonyms: GKKO, GLK-
Gene: Gck  Location: Chr11:5900820-5950081 bp, - strand  Genetic Position: Chr11, 3.88 cM
Germline Transmission:  Earliest citation of germline transmission: J:29255
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced all of exon 4 and parts of exons 3 and 5 of the gene. Northern blots of liver from heterozygous and homozygous mutant mice showed decreased levels of mRNA and no detectable mRNA, respectively, for the gene of interest. Enzymatic activity in both pancreatic islet cells and liver from heterozygous mutant mice was approximately 60% of wild-type littermates. Enzymatic activity in liver from homozygous mutant mice was undetectable. (J:29255)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gck Mutation:  24 strains or lines available
Original:  J:29255 Grupe A, et al., Transgenic knockouts reveal a critical requirement for pancreatic beta cell glucokinase in maintaining glucose homeostasis. Cell. 1995 Oct 6;83(1):69-78
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
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