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Tnfrsf1atm1Imx
Targeted Allele Detail
Nomenclature
Symbol: Tnfrsf1atm1Imx
Name: tumor necrosis factor receptor superfamily, member 1a; targeted mutation 1, Immunex Research and Development Corporation
MGI ID: MGI:1857468
Synonyms: p55-, p55 KO, Preschon Tnfrsf1a-, TNF-alpha-R1, TNFR-, TNFR1-, TNFRI-, Tnfrsf1atm1Imx
Gene: Tnfrsf1a  Location: Chr6:125349362-125362484 bp, + strand  Genetic Position: Chr6, 59.32 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:45147
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA PGK-neomycin resistance cassette replaced 4kb of sequence, including exons 2 to 5 (amino acids 30 - 184). Lack of gene product was shown functionally. (J:45147, J:110548)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Tnfrsf1a Mutation:  33 strains or lines available
References
Original:  J:45147 Peschon JJ, et al., TNF receptor-deficient mice reveal divergent roles for p55 and p75 in several models of inflammation. J Immunol. 1998 Jan 15;160(2):943-52
All:  303 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory