Tnfrsf1a^tm1Imx
Targeted Allele Detail

Summary

• Symbol: Tnfrsf1a^tm1Imx
• Name: tumor necrosis factor receptor superfamily, member 1a; targeted mutation 1, Immunex Research and Development Corporation
• MGI ID: MGI:1857468
• Synonyms: p55-, p55 KO, Preschon Tnfrsf1a^-, TNF-alpha-R1, TNFR^-, TNFR1-, TNFRI-, Tnfrsf1^atm1Imx
• Gene: Tnfrsf1a Location: Chr6:125326686-125339446 bp, + strand Genetic Position: Chr6, 59.32 cM
• Alliance: Tnfrsf1a^tm1Imx page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:45147
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neomycin resistance cassette replaced 4kb of sequence, including exons 2 to 5 (amino acids 30 - 184). Lack of gene product was shown functionally. (J:45147, J:110548)

Disease models

Expression

In Mice Carrying this Mutation:	81 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 6 strains available Cell Lines: 0 lines available
• Carrying any Tnfrsf1a Mutation: 47 strains or lines available

References

• Original: J:45147 Peschon JJ, et al., TNF receptor-deficient mice reveal divergent roles for p55 and p75 in several models of inflammation. J Immunol. 1998 Jan 15;160(2):943-52
• All: 391 reference(s)