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Targeted Allele Detail
Symbol: Mdm2tm1Bay
Name: transformed mouse 3T3 cell double minute 2; targeted mutation 1, Baylor College of Medicine
MGI ID: MGI:1857463
Synonyms: Mdm2-, Mdm2delta7-12, mdm2ml
Gene: Mdm2  Location: Chr10:117688875-117710758 bp, - strand  Genetic Position: Chr10, 66.32 cM, cytoband C1-C3
Germline Transmission:  Earliest citation of germline transmission: J:29811
Parent Cell Line:  AB2.1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsAn hprt reporter replaced a 7.1 kb fragment of the gene encompassing all of exons 7 through 11 and a portion of exon 12. The deleted region encoded all of the putative transcription function motifs of the protein. (J:29811, J:81065)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 2 assay results
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mdm2 Mutation:  24 strains or lines available
Original:  J:29811 Jones SN, et al., Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53. Nature. 1995 Nov 9;378(6553):206-8
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory