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Targeted Allele Detail
Symbol: Adra2atm1Lel
Name: adrenergic receptor, alpha 2a; targeted mutation 1, Lee E Limbird
MGI ID: MGI:1857459
Synonyms: alpha2A-ARD79N, D79N
Gene: Adra2a  Location: Chr19:54045182-54048982 bp, + strand  Genetic Position: Chr19, 49.04 cM
Germline Transmission:  Earliest citation of germline transmission: J:34820
Parent Cell Line:  D3H (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Nucleotide substitutions
Mutation detailsPoint mutations were introduced to alter the codon at position 79 from one encoding aspartic acid to one encoding asparagine. RNase protection assays indicated that normal levels of transcript were produced from this allele, but binding assays indicated that no functional protein was present in isolated brain membranes of homozygous mice. (J:34820)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Adra2a Mutation:  14 strains or lines available
Original:  J:34820 MacMillan LB, et al., Central hypotensive effects of the alpha2a-adrenergic receptor subtype. Science. 1996 Aug 9;273(5276):801-3
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
The Jackson Laboratory