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Il2rgtm1Wjl
Targeted Allele Detail
Summary
Symbol: Il2rgtm1Wjl
Name: interleukin 2 receptor, gamma chain; targeted mutation 1, Warren J Leonard
MGI ID: MGI:1857455
Synonyms: CD132-, gammac-, gc-, IL2Rgammanull, Il2rgtm1Wjll, [KO]gammac
Gene: Il2rg  Location: ChrX:100307991-100311861 bp, - strand  Genetic Position: ChrX, 43.9 cM
Alliance: Il2rgtm1Wjl page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:24117
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced part of exon 3 and all of exons 4 - 8 of the gene, resulting in the loss of most of the extracellular domain and all of the transmembrane and cytoplasmic domains of the protein. (J:24117)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 73 strains available      Cell Lines: 0 lines available
Carrying any Il2rg Mutation:  137 strains or lines available
References
Original:  J:24117 Cao X, et al., Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain. Immunity. 1995 Mar;2(3):223-38
All:  454 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/22/2022
MGI 6.22
The Jackson Laboratory