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Targeted Allele Detail
Symbol: Srd5a1tm1Mahe
Name: steroid 5 alpha-reductase 1; targeted mutation 1, Mala Mahendroo
MGI ID: MGI:1857454
Synonyms: 5alphaRKO, Srd5a1-
Gene: Srd5a1  Location: Chr13:69573449-69611442 bp, - strand  Genetic Position: Chr13, 35.55 cM
Germline Transmission:  Earliest citation of germline transmission: J:32217
Parent Cell Line:  JH1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA region encompassing promoter region and the a 3' portion of exon 1, encoding thr first 36 amino acids, was replaced by a neomycin selection cassette. Northern blot analysis of total RNA isolated from several organs showed an absence of transcript in homozygous mutant mice. (J:32217)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Srd5a1 Mutation:  8 strains or lines available
Original:  J:32217 Mahendroo MS, et al., 5 alpha-reduced androgens play a key role in murine parturition. Mol Endocrinol. 1996 Apr;10(4):380-92
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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