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Nf1tm1Fcr
Targeted Allele Detail
Nomenclature
Symbol: Nf1tm1Fcr
Name: neurofibromatosis 1; targeted mutation 1, Fredrick Cancer Research and Development Center
MGI ID: MGI:1857444
Synonyms: Nf1-, Nf1Fcr, Nf1mut
Gene: Nf1  Location: Chr11:79339693-79581612 bp, + strand  Genetic Position: Chr11, 46.74 cM, cytoband B4-5
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:18048
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation details
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 6 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Nf1 Mutation:  20 strains or lines available
Notes
Phenotypic Similarity to Human Syndrome: Glioblastoma Multiforme (in combination with neuronal deletion of Trp53, J:149662)

References
Original:  J:18048 Brannan CI, et al., Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues [published erratum appears in Genes Dev 1994 Nov 15;8(22):2792]. Genes Dev. 1994 May 1;8(9):1019-29
All:  55 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory