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Targeted Allele Detail
Symbol: L1camtm1Sor
Name: L1 cell adhesion molecule; targeted mutation 1, Philippe Soriano
MGI ID: MGI:1857443
Synonyms: L1-
Gene: L1cam  Location: ChrX:73853778-73880838 bp, - strand  Genetic Position: ChrX, 37.43 cM, cytoband A6-B
Cerebellar abnormalities in L1camtm1Sor/Y Nrcamtm1Gmt/Nrcamtm1Gmt mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:45013
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced the exons encoding the sixth immunoglobulin-like domain of the protein. Immunoblots of lysates of adult brains from homozygous mutant mice showed an absence of normal protein. (J:45013)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 3 assay results
In Structures Affected by this Mutation: 14 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any L1cam Mutation:  9 strains or lines available
Original:  J:45013 Cohen NR, et al., Errors in corticospinal axon guidance in mice lacking the neural cell adhesion molecule L1. Curr Biol. 1998 Jan 1;8(1):26-33
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory