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Il1r1tm1Roml
Targeted Allele Detail
Nomenclature
Symbol: Il1r1tm1Roml
Name: interleukin 1 receptor, type I; targeted mutation 1, Mark A Labow
MGI ID: MGI:1857441
Synonyms: IL-1RI-, IL-1RI-deficient, IL-1rKO
Gene: Il1r1  Location: Chr1:40225080-40317257 bp, + strand  Genetic Position: Chr1, 18.81 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:42373
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced an ~ 1 kb region of the DNA and included one exon of the gene, which encodes the signal peptide and contains a possible ATG initiation codon. (J:42373)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Il1r1 Mutation:  23 strains or lines available
References
Original:  J:42373 Labow M, et al., Absence of IL-1 signaling and reduced inflammatory response in IL-1 type I receptor-deficient mice. J Immunol. 1997 Sep 1;159(5):2452-61
All:  106 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory