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Il12rb1tm1Jm
Targeted Allele Detail
Nomenclature
Symbol: Il12rb1tm1Jm
Name: interleukin 12 receptor, beta 1; targeted mutation 1, Jeanne Magram
MGI ID: MGI:1857440
Synonyms: IL-12Rbeta1-, IL-12Rbeta1KO
Gene: Il12rb1  Location: Chr8:71261093-71274068 bp, + strand  Genetic Position: Chr8, 34.21 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:42105
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced exons 1 to 3 of the gene, deleting the ATG translation initiation codon and causing a frame-shift in the translation reading frame. (J:42105)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Il12rb1 Mutation:  24 strains or lines available
References
Original:  J:42105 Wu C, et al., Characterization of IL-12 receptor beta1 chain (IL-12Rbeta1)-deficient mice: IL-12Rbeta1 is an essential component of the functional mouse IL-12 receptor. J Immunol. 1997 Aug 15;159(4):1658-65
All:  37 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory