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Htr2ctm1Jul
Targeted Allele Detail
Nomenclature
Symbol: Htr2ctm1Jul
Name: 5-hydroxytryptamine (serotonin) receptor 2C; targeted mutation 1, David Julius
MGI ID: MGI:1857439
Synonyms: 5-HT2cR-deficient
Gene: Htr2c  Location: ChrX:146962513-147197277 bp, + strand  Genetic Position: ChrX, 68.46 cM, cytoband D-F4
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:24339
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129S/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsInsertion of a nonsense mutation into exon 5 of the gene resulted in the introduction of a stop codon within the fifth putative transmembrane segment of the receptor and in the elimination of the carboxy-terminal half of the protein. (J:24339)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Htr2c Mutation:  10 strains or lines available
Notes
ES cell line = D3 (129S2/SvPas) or J1 (129S4/SvJae).
References
Original:  J:24339 Tecott LH, et al., Eating disorder and epilepsy in mice lacking 5-HT2c serotonin receptors [see comments]. Nature. 1995 Apr 6;374(6522):542-6
All:  34 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/27/2018
MGI 6.13
The Jackson Laboratory