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Fshbtm1Zuk
Targeted Allele Detail
Nomenclature
Symbol: Fshbtm1Zuk
Name: follicle stimulating hormone beta; targeted mutation 1, Martin M Matzuk
MGI ID: MGI:1857434
Synonyms: FSHbeta-, FSHbetaKO, fshbm1
Gene: Fshb  Location: Chr2:107056140-107059656 bp, - strand  Genetic Position: Chr2, 56.02 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:38099
Parent Cell Line:  AB2.1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAn HPRT minigene replaced a genomic fragment containing exons 1, 2 and part of 3. Northern blot analysis on RNA derived from pituitary of homozygous mice demonstrated that no detectable transcript was produced from thia allele. Radioimmunoasays on serum from homozygous mice confirmed that no functional protein was expressed from this allele. (J:38099)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 9 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fshb Mutation:  9 strains or lines available
References
Original:  J:38099 Kumar TR, et al., Follicle stimulating hormone is required for ovarian follicle maturation but not male fertility. Nat Genet. 1997 Feb;15(2):201-4
All:  30 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory