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Targeted Allele Detail
Symbol: Col3a1tm1Jae
Name: collagen, type III, alpha 1; targeted mutation 1, Rudolf Jaenisch
MGI ID: MGI:1857431
Gene: Col3a1  Location: Chr1:45311538-45349706 bp, + strand  Genetic Position: Chr1, 23.67 cM
Col3a1tm1Jae/Col3a1tm1Jae mouse with skin lesion

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:39273
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin selection cassette replaced a genomic fragment containing the promoter region and first exon of the gene. Protein analysis of isolated tail and skin collagens from homozygous mice demonstrated that no stable protein was produced from this allele. (J:39273)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 10 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Col3a1 Mutation:  4 strains or lines available
Original:  J:39273 Liu X, et al., Type III collagen is crucial for collagen I fibrillogenesis and for normal cardiovascular development. Proc Natl Acad Sci U S A. 1997 Mar 4;94(5):1852-6 SS 18 /C?
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory