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Targeted Allele Detail
Symbol: Ahrtm1Bra
Name: aryl-hydrocarbon receptor; targeted mutation 1, Christopher A Bradfield
MGI ID: MGI:1857427
Synonyms: Ahr-, AhrKO
Gene: Ahr  Location: Chr12:35497979-35534989 bp, - strand  Genetic Position: Chr12, 15.78 cM
Liver abnormalities in Ahrtm1Bra/Ahrtm1Bra mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:33827
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin selection cassette replaced a genomic fragment containing exon 2, which encodes the basic-HLH domain essential for dimerization and DNA binding. Western blot analysis on liver cytosol demonstrated that the protein was not detectable in homozygous mice. (J:33827)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 19 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Ahr Mutation:  86 strains or lines available
Original:  J:33827 Schmidt JV, et al., Characterization of a murine Ahr null allele: involvement of the Ah receptor in hepatic growth and development. Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6731-6
All:  113 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
The Jackson Laboratory