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E2f1tm1Meg
Targeted Allele Detail
Nomenclature
Symbol: E2f1tm1Meg
Name: E2F transcription factor 1; targeted mutation 1, Michael E Greenburg
MGI ID: MGI:1857424
Synonyms: E2f1-, E2F-1-
Gene: E2f1  Location: Chr2:154559407-154569892 bp, - strand  Genetic Position: Chr2, 76.79 cM
Neural defects are rescued in E2f1tm1Meg/E2f1tm1Meg H2-Oa/Brd2Tg(otx2-lacZ)F5pImat/H2-Oa/Brd2Tg(otx2-lacZ)F5pImat embryos

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:33100
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 72 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any E2f1 Mutation:  4 strains or lines available
References
Original:  J:33100 Field SJ, et al., E2F-1 functions in mice to promote apoptosis and suppress proliferation. Cell. 1996 May 17;85(4):549-61
All:  66 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory