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Targeted Allele Detail
Symbol: E2f1tm1Meg
Name: E2F transcription factor 1; targeted mutation 1, Michael E Greenburg
MGI ID: MGI:1857424
Synonyms: E2f1-, E2F-1-
Gene: E2f1  Location: Chr2:154559407-154569892 bp, - strand  Genetic Position: Chr2, 76.79 cM
Neural defects are rescued in E2f1tm1Meg/E2f1tm1Meg H2-Oa/Brd2Tg(otx2-lacZ)F5pImat/H2-Oa/Brd2Tg(otx2-lacZ)F5pImat embryos

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:33100
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsPart of exon 3, intron 3 and exon 4 were replaced with a neomycin cassette. These sequences encode residues encoding the leucine zipper and those critical for DNA binding. Northern blot analysis did not detect a transcript made from this allele in fibroblasts isolated from homozygous embryos. (J:33100)
View phenotypes for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 72 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any E2f1 Mutation:  4 strains or lines available
Original:  J:33100 Field SJ, et al., E2F-1 functions in mice to promote apoptosis and suppress proliferation. Cell. 1996 May 17;85(4):549-61
All:  68 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory