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Crhtm1Maj
Targeted Allele Detail
Nomenclature
Symbol: Crhtm1Maj
Name: corticotropin releasing hormone; targeted mutation 1, Joseph Majzoub
MGI ID: MGI:1857392
Synonyms: CRH -, CRHKO, CRH KO, CRH-KO
Gene: Crh  Location: Chr3:19693401-19695396 bp, - strand  Genetic Position: Chr3, 5.75 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:23082
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe sequences encoding the pre-propeptide region were replaced by a neomycin resistance cassette. RT-PCR analysis demonstrated that the transcript was absent in whole brain RNA derived from homozygous mice. Immunohistochemical analysis demonstrated that the protein was not detectable in sections of the amygdala and cerebral cortex of brains of homozygous mice. (J:17994, J:23082, J:47705)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 70 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Crh Mutation:  15 strains or lines available
References
Original:  J:23082 Muglia L, et al., Corticotropin-releasing hormone deficiency reveals major fetal but not adult glucocorticoid need. Nature. 1995 Feb 2;373(6513):427-32
All:  42 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/24/2015
MGI 5.21
The Jackson Laboratory