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Rb1tm2Mlh
Targeted Allele Detail
Nomenclature
Symbol: Rb1tm2Mlh
Name: RB transcriptional corepressor 1; targeted mutation 2, Martin L Hooper
MGI ID: MGI:1857341
Synonyms: Rbt19neo
Gene: Rb1  Location: Chr14:73194453-73325885 bp, - strand  Genetic Position: Chr14, 38.73 cM, cytoband D3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:2498
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsInsertion of a PGK-neomycin resistance cassette into exon 19 disrupted the Rb1 gene. The authors predict that the Rb1 reading frame would be truncated upstream of the coding sequence for T-antigen binding domain number 2, and that therefore any gene product will be non functional. (J:2498)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 9 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rb1 Mutation:  80 strains or lines available
References
Original:  J:2498 Clarke AR, et al., Requirement for a functional Rb-1 gene in murine development [see comments]. Nature. 1992 Sep 24;359(6393):328-30
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/06/2019
MGI 6.14
The Jackson Laboratory