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Ednrbs-1Chlc
Chemically induced Allele Detail
Nomenclature
Symbol: Ednrbs-1Chlc
Name: endothelin receptor type B; chlorambucil 1Chlc
MGI ID: MGI:1857326
Synonyms: Ednrbs-11R, s1ChLc, sOR-9Q
Gene: Ednrb  Location: Chr14:103814625-103844173 bp, - strand  Genetic Position: Chr14, 53.05 cM
Mutation
origin
Strain of Origin:  (101/Rl x C3H/Rl)F1
Mutation
description
Allele Type:    Chemically induced (other)
Mutation:    Undefined
 
Mutation details
Inheritance:    Recessive
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ednrb Mutation:  72 strains or lines available
Notes
This is one of the series of mutations induced by treatment of spermatogonia, spermatocytes, or spermatids with radiation or mutagenic chemicals. Mutants in general were recessive, with lethal effects in homozygotes or in compounds with other lethal mutations. Mutations were classified in an intersubspecific backcross for deletion of marker loci about 2 cM apart, D14Mit38 proximal, and D14Mit42 distal, to the Ednrb locus. In Ednrbs-1Chlc, induced by chlorambucil treatment of spermatids, neither flanking marker was deleted. Like the original Ednrbs-l mutation, Ednrbs-1Chlc causes juvenile lethality. This mutation may represent a deletion within the Ednrb locus only (J:16291).

References
Original:  J:10322 Rinchik EM, et al., Genetic and molecular analysis of chlorambucil-induced germ-line mutations in the mouse. Proc Natl Acad Sci U S A. 1990 Feb;87(4):1416-20
All:  4 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory