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Chemically induced Allele Detail
Symbol: Ednrbs-1Chlc
Name: endothelin receptor type B; chlorambucil 1Chlc
MGI ID: MGI:1857326
Synonyms: Ednrbs-11R, s1ChLc, sOR-9Q
Gene: Ednrb  Location: Chr14:103814625-103844173 bp, - strand  Genetic Position: Chr14, 53.05 cM
Strain of Origin:  (101/Rl x C3H/Rl)F1
Allele Type:    Chemically induced (other)
Mutation:    Undefined
Mutation detailsNo molecular defect was detected. These mice produce normal levels of transcript in adult brain, suggesting that the mutation affects important regulatory elements that mediate the expression of the gene during development. No genomic alterations identified within ~ 1.25 megabases surrounding the locus. (J:44601)
Inheritance:    Recessive
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ednrb Mutation:  57 strains or lines available
This is one of the series of mutations induced by treatment of spermatogonia, spermatocytes, or spermatids with radiation or mutagenic chemicals. Mutants in general were recessive, with lethal effects in homozygotes or in compounds with other lethal mutations. Mutations were classified in an intersubspecific backcross for deletion of marker loci about 2 cM apart, D14Mit38 proximal, and D14Mit42 distal, to the Ednrb locus. In Ednrbs-1Chlc, induced by chlorambucil treatment of spermatids, neither flanking marker was deleted. Like the original Ednrbs-l mutation, Ednrbs-1Chlc causes juvenile lethality. This mutation may represent a deletion within the Ednrb locus only (J:16291).

Original:  J:10322 Rinchik EM, et al., Genetic and molecular analysis of chlorambucil-induced germ-line mutations in the mouse. Proc Natl Acad Sci U S A. 1990 Feb;87(4):1416-20
All:  4 reference(s)

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