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Mpv17
Transgenic Allele Detail
Nomenclature
Symbol: Mpv17
Name: MpV17 mitochondrial inner membrane protein; Mpv17 retroviral insertion, kidney disease mutant
MGI ID: MGI:1857300
Synonyms: MPV-
Gene: Mpv17  Location: Chr5:31140654-31154251 bp, - strand  Genetic Position: Chr5, 17.12 cM
Transgene
origin
Strain of Origin:  CFW
Transgene
description
Transgene Type:    Transgenic
Mutation:    Insertion
 
Mutation detailsThe Mpv17 mutation was generated by infection of CFW preimplantation mouse embryos with a recombinant retrovirus, MPSVneo, which carries a neo gene and is a replication-defective derivative of the myeloproliferative sarcoma virus, a Moloney murine leukemia virus-related RNA virus. (J:10661)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 26 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mpv17 Mutation:  23 strains or lines available
References
Original:  J:10661 Weiher H, et al., Transgenic mouse model of kidney disease: insertional inactivation of ubiquitously expressed gene leads to nephrotic syndrome. Cell. 1990 Aug 10;62(3):425-34
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory