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Targeted Allele Detail
Symbol: Ifngr1tm1Agt
Name: interferon gamma receptor 1; targeted mutation 1, Michel Aguet
MGI ID: MGI:1857286
Synonyms: G129, IFN-gamma R-, IFN-gammaR-, IFN-gammaR-, IFN-gamma R0, IFN-gammaR0, IFN-gammaR1-, IFN-gammaRalpha_, IFN-gamma-R KO, IFN-gammaR KO, IFNgammaR KO, Ifngr-, Ifngr1-, IFNgR KO, IFn type II receptor
Gene: Ifngr1  Location: Chr10:19591949-19610229 bp, + strand  Genetic Position: Chr10, 8.49 cM
Trpm2tm1.1Alp/Trpm2tm1.1Alp and Ifngr1tm1Agt/Ifngr1tm1Agt mice exhibit increased susceptibility to bacterial infection

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:63815
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsInsertion of a neomycin cassette into exon V, which encodes an extracellular membrane-proximal portion of the receptor. (J:61321, J:63815, J:96036)
Inheritance:    Recessive
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 12 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 12 strains available      Cell Lines: 0 lines available
Carrying any Ifngr1 Mutation:  36 strains or lines available
Original:  J:63815 Huang S, et al., Immune response in mice that lack the interferon-gamma receptor [see comments]. Science. 1993 Mar 19;259(5102):1742-5
All:  501 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory