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Cdh1tm1Kem
Targeted Allele Detail
Nomenclature
Symbol: Cdh1tm1Kem
Name: cadherin 1; targeted mutation 1, Rolf Kemler
MGI ID: MGI:1857282
Synonyms: E-cad-
Gene: Cdh1  Location: Chr8:106603351-106670246 bp, + strand  Genetic Position: Chr8, 53.18 cM, cytoband D
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:19904
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsA lacZ gene and neomycin resistance cassette was inserted into exon 1 just upstream of the initiation codon of the gene. (J:19904)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cdh1 Mutation:  120 strains or lines available
References
Original:  J:19904 Larue L, et al., E-cadherin null mutant embryos fail to form a trophectoderm epithelium. Proc Natl Acad Sci U S A. 1994 Aug 16;91(17):8263-7
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/30/2020
MGI 6.15
The Jackson Laboratory