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Targeted Allele Detail
Symbol: Camk2atm1Sva
Name: calcium/calmodulin-dependent protein kinase II alpha; targeted mutation 1, Alcino Silva
MGI ID: MGI:1857279
Synonyms: alpha-CaMKII-, alphaCaMKII-, alphaCaMKIInull, Camk2atm1
Gene: Camk2a  Location: Chr18:60925618-60988152 bp, + strand  Genetic Position: Chr18, 34.41 cM
Germline Transmission:  Earliest citation of germline transmission: J:1421
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 130 bp DNA segment encoding the inhibitory domain and five amino acids of the calmodulin-binding domain was replaced with a neomycin selection cassette. Northern blot analysis on brain RNA derived from homozygous mice confirmed that no detectable transcript is produced from this allele. Western blot analysis on forebrain samples from homozygous mice demonstrated that no detectable protein is expressed from this allele. (J:1421)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Camk2a Mutation:  63 strains or lines available
Original:  J:1421 Silva AJ, et al., Deficient hippocampal long-term potentiation in alpha-calcium-calmodulin kinase II mutant mice [see comments]. Science. 1992 Jul 10;257(5067):201-6
All:  22 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory