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Targeted Allele Detail
Symbol: Aprttm1Jat
Name: adenine phosphoribosyl transferase; targeted mutation 1, Jay A Tischfield
MGI ID: MGI:1857278
Synonyms: Arpt-
Gene: Aprt  Location: Chr8:123301376-123303646 bp, - strand  Genetic Position: Chr8, 71.91 cM
Kidney histopathology of a Aprttm1Jat/AprttmiJat mouse

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:33255
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin cassette was inserted into exon 3. RT-PCR analysis did not detect any transcript produced from this allele in samples derived from liver or lung of homozygous mice. APRT protein activity was not detectable in eryothrocyte lysates or in liver extracts derived from homozygous mice. (J:33255)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Aprt Mutation:  15 strains or lines available
Original:  J:33255 Engle SJ, et al., Adenine phosphoribosyltransferase-deficient mice develop 2,8-dihydroxyadenine nephrolithiasis. Proc Natl Acad Sci U S A. 1996 May 28;93(11):5307-12
All:  17 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.21
The Jackson Laboratory