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Targeted Allele Detail
Symbol: Jak3tm1Ljb
Name: Janus kinase 3; targeted mutation 1, Leslie J Berg
MGI ID: MGI:1857276
Synonyms: Jak-3-, Jak3-
Gene: Jak3  Location: Chr8:71676296-71690575 bp, + strand  Genetic Position: Chr8, 34.43 cM
Germline Transmission:  Earliest citation of germline transmission: J:29722
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced a 0.6 kb fragment of the gene, which contains sequences encoding subdomains I to IV of the kinase domain. Protein immunoblots of lysates from bone marrow, spleen, and thymus showed no targeted protein. (J:29722)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Jak3 Mutation:  43 strains or lines available
Original:  J:29722 Thomis DC, et al., Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3. Science. 1995 Nov 3;270(5237):794-7
All:  31 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.10
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