About   Help   FAQ
Jak3tm1Ljb
Targeted Allele Detail
Nomenclature
Symbol: Jak3tm1Ljb
Name: Janus kinase 3; targeted mutation 1, Leslie J Berg
MGI ID: MGI:1857276
Synonyms: Jak-3-, Jak3-
Gene: Jak3  Location: Chr8:71676296-71690575 bp, + strand  Genetic Position: Chr8, 34.43 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:29722
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced a 0.6 kb fragment of the gene, which contains sequences encoding subdomains I to IV of the kinase domain. Protein immunoblots of lysates from bone marrow, spleen, and thymus showed no targeted protein. (J:29722)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Jak3 Mutation:  47 strains or lines available
References
Original:  J:29722 Thomis DC, et al., Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3. Science. 1995 Nov 3;270(5237):794-7
All:  31 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/15/2018
MGI 6.12
The Jackson Laboratory